This paper discusses social and ethical challenges that arise through the application of artificial intelligence on the genetic analysis of humans. AI can be used to calculate individuals’ polygenic scores which statistically predict character traits and behavioral dispositions. This technology might foster the selection of unborn children according to the likelihood of engaging in socially compliant behavior or developing a certain level of cognitive abilities. Through exercising moral and cognitive enhancements on individuals and groups, AI-enhanced personal eugenics runs the risk of undermining or destroying essential characteristics of humanity such as moral responsibility and autonomy. It is shown that an argument for the rejection of this technology requires certain philosophical or theological assumptions concerning the essence or teleology of human nature.