Next Generation-Sequencing is being applied in medical diagnostics increasingly. These new technologies differ from traditional medical interventions concerning their basic characteristics. Instead of the – in this case negligible – physical intervention, the robust informational intervention stands in the foreground. The original individual health claim is extended towards an individual treatment aim of preventive nature, but also towards a general interest to use medical information. Patients’ informed consent can follow these additional aims only in a limited way. In view of the new features of Next Generation- Sequencing technologies, the conventional protection of the patient is not sufficient when applying these in diagnostics.