This book is intended as a comprehensive defense of psycho-physical dualism. It gives answers to the question of what dualism may consist in, and inquires into the broadly cultural motivation behind accepting dualism or its opponent physicalism. Arguments for dualism, among them strengthened versions of the famous classical arguments, are presented and defended against objections. Moreover, the various general objections to dualism are criticized in detail, for example, the allegation that dualism is of an anti-scientific nature. The book issues into developing the outlines of a dualistic theory of consciousness and agency. The theory outlined is not only compatible with science but actually connects with it. It offers a unified perspective on the phenomenon of conscious life and may serve as a basis for a general ethics regarding all conscious living beings.